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The First Function of Insulin

To be physiologically correct one must note that the first and perhaps most important role of insulin is not to transport glucose into the cell but rather to signal the liver into producing the enzymes that are necessary for proper metabolism.

Since most diabetes reviews and articles focus so intensely on the chemical role of insulin in reference to the cell, this first in time and essential function of insulin goes almost completely unnoticed and not commented upon. 

It is this oversight, brought on by focusing and examining closely all chemical insulin interactions at the cellular level, that has led to ignoring the primary role of insulin in stimulating the liver as an organ.  This may be a classic case of missing the forest for the trees. In a healthy person the liver receives oscilations of insulin at a sufficiently high threshold that causes the liver to release into the blood stream a series of enzimes that are needed for all of the cells in the body to metabolize sugars properly.

For a person with diabetes the liver is not receiving the proper insulin oscillations and threshold to activate and release all of these important metabolic enzimes. The Artificial Pancreas Treatment mimics the pancreas of a healthy person by sending out pulses of insulin at the proper frequency and threshold amplitude to activate the liver.

The result is that during the treatment the patient can become more metabolically normal in all of the cells of their body. Once the cells have the necessary cellular energy (ATP) from proper metabolism they begin to repair and perform the function they are supposed to.

Created on 2012-02-25 at 09:08:43 PM.